Antihistamine:

Symptomatic relief of allergy such as hay fever, urticaria

10 mg daily or 5 mg twice daily

Molecular weight :461.8

%Protein binding :93

%Excreted unchanged in urine : 50–60

Volume of distribution (L/kg) :0.45

half-life – normal/ESRD (hrs) :8–10/20

20 to 50 : Dose as in normal renal function

10 to 20 : Dose as in normal renal function

<10 : 5–10 mg daily

CAPD :Unlikely dialysability. Dose as in GFR <10 mL/min

HD :Not dialysed. Dose as in GFR <10 mL/min

HDF/high flux :Not dialysed. Dose as in GFR <10 mL/min

CAV/VVHD :Unknown dialysability. Dose as in normal renal function

Potentially hazardous interactions with other drugs

None known

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Oral

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Available as tablets and solution

Manufacturers recommend halving dose in renal impairment

Dose may be titrated up but may result in increased sedation

Less than 10% of a dose is removed by haemodialysis